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American Society of Microbiology ABMM Sample Questions:

1. A patient presents with a chronic cough, weight loss, and night sweats. Chest X-ray shows cavitarylesions in the upper lobes. Sputum is acid-fast positive. Drug susceptibility testing reveals resistance to isoniazid but susceptibility to rifampin, ethambutol, and pyrazinamide. The MOST appropriate treatment regimen should include:

A) Isoniazid, ethambutol, and pyrazinamide
B) Isoniazid and rifampin
C) Rifampin, ethambutol, and pyrazinamide
D) Isoniazid, rifampin, pyrazinamide, and ethambutol

2. A child presents with a characteristic "slapped cheek" rash followed by a lacy, reticular rash on the trunk and extremities. The causative agent is a single-stranded DNA virus belonging to the family Parvoviridae, known as:

A) Human parvovirus B19
B) Roseola virus (HHV-6)
C) Rubella virus
D) Measles virus

3. A patient with a history of solid organ transplantation develops a severe respiratory illness. Bronchoalveolar lavage fluid is positive for cytomegalovirus (CMV) DNA by PCR, and cytological examination reveals characteristic "owl's eye" inclusions in enlarged cells. The MOST appropriate management strategy for this patient would include:

A) Supportive care and monitoring for spontaneous resolution.
B) Initiation of broad-spectrum antibiotics to cover potential bacterial coinfections.
C) Treatment with antiviral agents such as ganciclovir or valganciclovir.
D) Administration of corticosteroids to reduce inflammation.

4. Which of the following bacterial genera inherently possesses D-alanyl-D-lactate peptide subunits in its peptidoglycan precursors, conferring natural, high-level resistance to vancomycin?

A) Leuconostoc
B) Staphylococcus
C) Enterococcus (e.g., E. gallinarum, E. casseliflavus carrying vanC)
D) Streptococcus

5. A researcher is studying the genetic relatedness of different isolates of Mycobacterium tuberculosis. Which of the following molecular typing methods provides the highest discriminatory power for distinguishing between closely related strains?

A) Whole-genome sequencing (WGS)
B) Spoligotyping
C) Pulsed-field gel electrophoresis (PFGE)
D) Restriction fragment length polymorphism (RFLP) analysis

Solutions: